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SRP4388 Sigma-Aldrich

SDF-1alpha (CXCL12) from mouse

recombinant, expressed in E. coli, ≥99% (SDS-PAGE), ≥99% (HPLC)

Synonym: CXCL12, PBSF, Pre-B cell growth-stimulating factor, SDF-1, chemokine (C-X-C motif) ligand 12, hIRH



Related Categories Cell Biology, Cell Signaling and Neuroscience, Chemokines, Cytokines, Cytokines and Growth Factors,
biological source   mouse
recombinant   expressed in E. coli
assay   ≥99% (HPLC)
  ≥99% (SDS-PAGE)
form   lyophilized
potency   50-100 ng/mL
mol wt   ~7.9 kDa
packaging   pkg of 10 μg
storage condition   avoid repeated freeze/thaw cycles
impurities   endotoxin, tested
NCBI accession no.   P40224
shipped in   wet ice
storage temp.   −20°C
Gene Information   mouse ... Sdf1(20315)



Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitution in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.

Physical form

Lyophilized from 10 mM acetic acid. The protein may appear as a haze or film, which is difficult to see at the bottom of the vial.

Biochem/physiol Actions

Stromal Cell-Derived Factor-1α (SDF-1α) is a pleiotropic chemokine. It works as a chemoattractant for T- and B-lymphocytes and inflammatory monocytes. In neural stem cells, SDF-1α is needed for proliferation, survival, migration, intercellular interaction and guidance to neuronal axon. It is responsible for pathogenic inflammation in the central nervous system (CNS). It also controls BMP (bone morphogenic protein)-associated osteogenic differentiation.

General description

Stromal Cell-Derived Factor-1α (SDF-1α) is a recently discovered protein belonging to the α-chemokine (C-X-C) family of cytokines. Recombinant mouse SDF-1α is a 7.9kDa protein containing 68 amino acids residues.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


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