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SRP4524 Sigma-Aldrich

BD-3 human

recombinant, expressed in E. coli

Synonym: DEFB103, DEFB3, HBD3, HBP3, HDB-3

  •  NACRES NA.32

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Properties

Related Categories Antibiotics, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure Class,
biological source   human
recombinant   expressed in E. coli
form   lyophilized
mol wt   ~5 kDa
packaging   pkg of 20 μg
storage condition   avoid repeated freeze/thaw cycles
impurities   endotoxin, tested
NCBI accession no.   P81534
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... DEFB103A(414325)

Description

General description

Chemical structure: peptide

β-defensin-3 (BD-3) is an anti-microbial peptide produced by airway epithelial cells, lung-derived epithelial cells and keratinocytes. It has a molecular weight of 5kDa. The gene encoding this protein is localized on human chromosome 8p23.1. Recombinant human β-defensin-3 (BD-3) is an antimicrobial peptide, which belongs to the distinct family of β-defenisns. Recombinant human BD-3 is a 5.1 kDa protein containing 45 amino acid residues.

Biochem/physiol Actions

β-defensin-3 (BD-3) associates with bacterial products which reduce the effect of inflammatory cytokine responses. The protein has been shown to stimulate the production of interferon-α and activate monocytes through toll-like receptors 1 and 2. It antagonizes the activation of C-X-C motif chemokine receptor 4 (CXCR4).

Physical form

Sterile filtered and lyophilized with no additives.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in 10 mM Acetic acid to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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