SRP4542 Sigma-Aldrich

FGF-19 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym: FGF19, FGFJ, fibroblast growth factor 19



Related Categories Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines, Cytokines and Growth Factors,
biological source   human
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   lyophilized
potency   50-200 ng/mL
mol wt   ~21.8 kDa
packaging   pkg of 25 μg
storage condition   avoid repeated freeze/thaw cycles
impurities   endotoxin, tested
NCBI accession no.   NM_005117
UniProt accession no.   O95750
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... FGF19(9965)


General description

Fibroblast growth factor-19 (FGF-19) is an ileum-derived polypeptide hormone and a high affinity heparin-dependent ligand for fibroblast growth factor receptor 4 (FGFR4). It is part of the hormone-like FGF family. The gene encoding FGF-19 is localized on human chromosome 11q13.3. Recombinant human FGF-19 is a 21.8kDa protein containing 195 amino acid residues.

Biochem/physiol Actions

Fibroblast growth factor-19 (FGF-19) is involved in the gut-liver signaling pathway and modulation of bile acid synthesis. Once secreted, it binds to the hepatic fibroblast growth factor receptor 4 (FGFR4)/Klotho-β cell-surface receptor complex and activates it. FGF-19 promotes glycogen synthesis, protein synthesis and lipid metabolism.

Physical form

Lyophilized from 5 mM Tris, pH 7.6 plus 75 mM NaCl. The protein may appear as a haze or film, which you may not see at the bottom of the vial.


Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1 to 1.0 μg/μL. This solution can then be diluted into other aqueous buffers.

Safety & Documentation

Safety Information

WGK Germany 


Certificate of Analysis


Request a Serum Sample

Cell Culture Guide
Protocols & Articles


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