EMAIL THIS PAGE TO A FRIEND
SRP4576 Sigma-Aldrich

BMP-11 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonym: BMP 11, GDF11, Growth/Differentiation Factor-11, bone morphogenetic protein 11

  •  NACRES NA.32

Purchase

Properties

Related Categories BMPs and Receptors, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors,
biological source   human
recombinant   expressed in E. coli
assay   ≥98% (HPLC)
  ≥98% (SDS-PAGE)
form   lyophilized
mol wt   ~32.6 kDa
packaging   pkg of 10 μg
storage condition   avoid repeated freeze/thaw cycles
impurities   endotoxin, tested
NCBI accession no.   O95390
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... GDF11(10220)

Description

General description

BMPs (bone morphogenetic proteins) belong to the transforming growth factor-β (TGF-β) superfamily of structurally related signaling proteins. BMP-11 is also known as growth differentiation factor 11 (GDF11). Recombinant human BMP-11 is a N-terminus His-tagged protein with a molecular weight of 32.6kDa (for homodimeric) and 16.2kDa (for monomeric) consisting of 136 amino acid polypeptide chains.

Biochem/physiol Actions

As implied by their name, bone morphogenetic proteins (BMPs) promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. They also enhance protein degradation and reduce skeletal muscle protein synthesis. BMP-11 may have a role in the development of the nervous system in mice. It acts as a modulator of development and differentiation. In mice, circulating levels of BMP-11 decrease with age.

Physical form

Lyophilized from 10 mM Sodium Citrate, pH 3.5.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute to a concentration of 0.1-1.0 mg/mL in water containing BSA (50 μg BSA per 1 μg of protein). This solution can then be diluted into other aqueous buffers.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Related Content

Cell Culture Troubleshooting Guide

Cell culture has become one of the most fundamental techniques for modeling biological systems, and is of increasing importance in the biotechnology and pharmaceutical sectors as well as an essential...
Keywords: Antibiotics, Apoptosis, Cell attachment, Cell culture, Cryopreservation, Filtration, Growth factors, Pharmaceutical, Phase transitions

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?