EMAIL THIS PAGE TO A FRIEND
SRP4581 Sigma-Aldrich

BMP-10 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonym: BMP 10, bone morphogenetic protein 10

Purchase

Properties

Related Categories BMPs and Receptors, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors,
biological source   human
recombinant   expressed in E. coli
assay   ≥98% (HPLC)
  ≥98% (SDS-PAGE)
form   lyophilized
mol wt   mol wt ~32 kDa
packaging   pkg of 20 μg
storage condition   avoid repeated freeze/thaw cycles
impurities   endotoxin, tested
NCBI accession no.   O95393
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... BMP10(27302)

Description

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute to a concentration of 0.1-1.0 mg/mL in water containing BSA (50 mg BSA per 1 mg of protein). This solution can then be diluted into other aqueous buffers

Physical form

Sterile filtered and Lyophilized without additives.

Biochem/physiol Actions

Bone morphogenetic protein 10 (BMP10) acts as a potent tumor suppressor in prostate, gastric and breast cancer. It is implicated in trabeculation of the embryonic heart. BMP10 retards the growth of prostate cancer cells via, apoptosis induced by X- inhibitor of apoptosis protein (XIAP) and extracellular signal–regulated kinase (ERK)1/2 dependent signaling and SMAD-independent signaling. In addition, it also has an ability to inhibit prostate cancer cell migration and invasiveness. Elevated expression of the gene inhibits growth, adhesion and migration of bladder cancer cells in vitro. Thus, this protein can be considered as a potent therapeutic target for bladder cancer.

General description

BMPs (bone morphogenetic proteins) belong to the TGF-β superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP-10 is essential for the proper development of the heart, but is not expressed until after cardiac patterning or looping are completed. Recombinant human BMP-10 is a 32 kDa disulfide-linked homodimer containing two 142 amino acid polypeptide chains.

The bone morphogenetic protein 10 (BMP10) gene spans ~7.8 kb on human chromosome 2p13.3. It is highly expressed in the trabeculae of the embryonic heart, but it is expressed at low levels in the liver and the lungs. BMP-10 belongs to the bone morphogenetic protein (BMP) family.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


Request a Serum Sample

Cell Culture Guide
Protocols & Articles

Related Content

Cell Culture Troubleshooting Guide

Cell culture has become one of the most fundamental techniques for modeling biological systems, and is of increasing importance in the biotechnology and pharmaceutical sectors as well as an essential...
Keywords: Antibiotics, Apoptosis, Cell attachment, Cell culture, Cryopreservation, Filtration, Growth factors, Pharmaceutical, Phase transitions

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?