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SRP4589 Sigma-Aldrich

FGF-20 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym: FGF20, FGFK, Fibroblast growth factor 20

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Properties

Related Categories Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines, Cytokines and Growth Factors,
biological source   human
recombinant   expressed in E. coli
assay   ≥90% (SDS-PAGE)
form   lyophilized
mol wt   ~24 kDa
packaging   pkg of 20 μg
storage condition   avoid repeated freeze/thaw cycles
impurities   endotoxin, tested
NCBI accession no.   Q9NP95
UniProt accession no.   Q9NP95
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... FGF20(26281)

Description

General description

The gene FGF20 (fibroblast growth factor 20) is mapped to human chromosome 8p22-p21.3. It is strongly expressed in the substantia nigra of the brain. It is also expressed during early embryonic development. FGF20 belongs to the FGF class of genes.

Biochem/physiol Actions

FGF20 (fibroblast growth factor 20) is a neurotrophin which plays an important role in growth and survival of neurons. It is mainly required for the survival of dopaminergic cells. It plays an important role in central nervous development and function. FGF20 interacts with the tyrosine kinase FGF receptor-1 (FGFR1). Mutation in FGF20 (rs12720208) is associated with the susceptibility of Parkinson′s disease. It is also a putative proto-oncogene. It is required for maintaining the Wnt/β-catenin pathway-mediated anchorage-independent cellular growth.

Physical form

Lyophilized from 20 mM Tris, pH 7.6, containing 1.5 M NaCl.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1 to 1.0 mg/mL. This solution can then be diluted into other aqueous buffers.

Safety & Documentation

Safety Information

WGK Germany 
3

Documents

Certificate of Analysis

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Cell Culture Guide
Protocols & Articles

Articles

Fibroblast Growth Factor Family (FGF)

Fibroblast Growth Factors (FGFs) are potent regulators of cell proliferation, differentiation and function and are critically important in normal development, tissue maintenance, wound repair and ang...
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Peer-Reviewed Papers
15

References

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