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SRP4595 Sigma-Aldrich

IFN-alpha 2b human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonym: IFNA, INFA2, Interferon α 2b

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Properties

Related Categories Bioactives/Supplements, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors,
biological source   human
recombinant   expressed in E. coli
assay   ≥98% (HPLC)
  ≥98% (SDS-PAGE)
form   lyophilized
potency   2.6x10^8 units/mg
mol wt   ~19.3 kDa
packaging   pkg of 100 μg
storage condition   avoid repeated freeze/thaw cycles
impurities   endotoxin, tested
NCBI accession no.   Q86UP4
UniProt accession no.   Q86UP4
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... IFNA2b(3440)

Description

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 1 mg/mL. This solution can then be diluted into other aqueous buffers.

Physical form

Lyophilized from 5 mM sodium phosphate, pH 7.4.

Application

IFN-α2b (interferon α 2b)-human has been used to study role of USP18 (ubiquitin specific peptidase 18)-mediation deISGylation in controlling cellular autophagy upon treatment with type I interferons.

Biochem/physiol Actions

IFN-α2b (interferon α 2b) is a lymphoid factor that possesses potent anti-viral activity. It mainly interacts with cell surface-specific receptors. This interaction is responsible for anti-pathogenic response in cells. IFN-α2b also exhibits anti-tumor activities. Humans with brain tumor were shown to have mutations in this gene.

General description

The gene IFN-α2b (interferon α 2b) is mapped to human chromosome 9. The encoded protein is a type 1 interferon and a glycoprotein. It belongs to the class of cytokines. Human IFN-α2b is a 19.3kDa protein containing 165 amino acid residues.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


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Cell Culture Guide
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Peer-Reviewed Papers
15

References

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