SRP4745 Sigma-Aldrich

TFF-2 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonym: SML1, SP, TFF2, Trefoil Factor 2, Trefoil Factor peptide, pS2 protein



Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, Extracellular Matrix, Extracellular Matrix Peptides and Proteins More...
biological source   human
recombinant   expressed in E. coli
assay   ≥98% (HPLC)
  ≥98% (SDS-PAGE)
form   lyophilized
mol wt   ~12.0 kDa
packaging   pkg of 20 μg
storage condition   avoid repeated freeze/thaw cycles
impurities   endotoxin, tested
NCBI accession no.   Q03404
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... TFF2(7032)


General description

Trefoil factor 2 (TFF2), also known as spasmolytic polypeptide, belongs to trefoil factor family (TFF). It is encoded by the gene mapped to human chromosome 21q22.3. The encoded protein consists of two trefoil domains and is primarily expressed along with mucin MUC6 in the gastric epithelium and duodenal Brunner′s glands. Recombinant human TFF2 is a 12.0kDa polypeptide of 106 amino acid residues, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.

Biochem/physiol Actions

Trefoil factor family (TFF) members play a vital role in mucus stabilization and stimulation of normal epithelial cell restitution during wound healing via motogenic and antiapoptotic activities. TFF2 is implicated in regulation of gastric mucosal integrity and may hinder tumorigenesis in the stomach. Multiple organ dysfunction syndrome (MODS) patients show elevated expression of TFF2. Overexpression of TFF2 is observed in various gastrointestinal tract disorders, such as gastric ulceration, duodenal ulceration, and Crohn disease of the small intestine. TFF2 stimulates cell migration through activation of protease-activated receptor 4 (PAR4).

Physical form

Sterile filtered and lyophilized powder.


Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1-1.0 ug/ul. The solution can then be diluted into other aqueous buffers.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.


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