SRP4893 Sigma-Aldrich

TFF1 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonym: BCEI, HP1, HPS, TFF-1, TFF1, pS2



Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, Extracellular Matrix, Extracellular Matrix Peptides and Proteins More...
biological source   human
recombinant   expressed in E. coli
assay   ≥98% (HPLC)
  ≥98% (SDS-PAGE)
form   lyophilized
mol wt   mol wt ~8.2 kDa
packaging   pkg of 20 μg
storage condition   avoid repeated freeze/thaw cycles
impurities   endotoxin, tested
NCBI accession no.   P04155
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... TFF1(7031)



Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.

Physical form

Sterile filtered and lyophilized powder.

Biochem/physiol Actions

Trefoil factor family (TFF) members play a vital role in mucus stabilization and stimulation of normal epithelial cell restitution during wound healing via motogenic and antiapoptotic activities. TFF1 prevents anoikis, chemicals or bad-induced apoptosis by decreasing the caspase-3, caspase-6, caspase-8, and caspase-9 activities. TFF1 functions as a tumor suppressor in gastric cancer, whereas it acts as a tumor promoter in mucinous ovarian cancer via regulating the Wnt/β-catenin signaling pathway. Elevated level of TFF1 is observed in patients suffering from Chronic kidney disease (CKD). TFF1 might function as a biomarker for early detection of CKD.

General description

Trefoil factor 1(TFF1) is a member of trefoil factor family (TFF) and is encoded by the gene mapped to human chromosome 21q22.3. Recombinant human TFF1 is an 8.2kDa polypeptide containing 60 amino acid residues. TFF1 consists of trefoil motif, which is a 40-amino acid domain with three conserved disulfides. TFF1 is expressed and secreted by epithelial cells in the stomach or colon mucous membrane.

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