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SRP5175 Sigma-Aldrich

CDKN3, GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym: CDI1, CIP2, FLJ25787, KAP1, KAP, MGC70625

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Properties

Related Categories Apoptosis and Cell Cycle, Cell Biology, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Cell Signaling and Neuroscience More...
recombinant   expressed in baculovirus infected Sf9 cells
assay   ≥70% (SDS-PAGE)
form   buffered aqueous glycerol solution
mol wt   ~51 kDa
NCBI accession no.   NM_005192
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... CDKN3(1033)

Description

General description

CDKN3 is a member of the dual specificity protein phosphatase family that acts as a cyclin-dependent kinase inhibitor. CDKN3 has been shown to interact with and dephosphorylate specifically the CDK2 kinase thereby preventing it’s activation. CDKN3 has been reported to be deleted, mutated, or overexpressed in several kinds of cancers. Increased expression of CDKN3 leads to increased levels of kinase-associated phosphatase activity that inhibits the G(1)/S transition of the cell cycle by dephosphorylating the cyclin-dependent kinases.

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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