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SRP5327 Sigma-Aldrich

BUB1B, active, GST tagged human

PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym: BUB1beta, BUBR1, Bub1A, MAD3L, SSK1, hBUBR1



Related Categories Active Kinases, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology
biological source   human
recombinant   expressed in baculovirus infected Sf9 cells
product line   PRECISIO®
assay   ≥70% (SDS-PAGE)
form   buffered aqueous glycerol solution
specific activity   1.2-1.8 nmol/min·mg
mol wt   ~73 kDa
application(s)   cell analysis: suitable
NCBI accession no.   NM_001211
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... BUB1B(701)


General description

BUB1B or budding uninhibited by benzimidazoles 1 homolog beta is involved in spindle checkpoint function and has been localized to the kinetochore. BUB1B plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. BUB1B links the regulation of chromosome-spindle attachment to mitotic checkpoint signaling. BUB1B expression during the spindle checkpoint is dependent on residual BUB1B expression and impaired spindle checkpoint function has been found in many forms of cancer. BUB1B is essential for early embryonic development and normal hematopoiesis.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Preparation Note

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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