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SRP6005 Sigma-Aldrich

FGF-21 murine

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

Synonym: FGF21, FGFL, Fibroblast growth factor 21

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Properties

Related Categories Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones,
biological source   mouse
recombinant   expressed in E. coli
assay   ≥95% (HPLC)
  ≥95% (SDS-PAGE)
form   lyophilized
mol wt   20.1 kDa
packaging   pkg of 10 μg
impurities   Endotoxin, tested
NCBI accession no.   Q9JJN1
UniProt accession no.   Q9JJN1
shipped in   wet ice
storage temp.   −20°C
Gene Information   mouse ... FGF-21(56636)

Description

General description

Fibroblast Growth Factor-21 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 183 amino acids including N-terminal methionine and having a molecular mass of 20.1kDa. The amino acid sequence of the recombinant mouse FGF21 is 100% homologous to the amino acid sequence of the mouse FGF21 without signal sequence.The FGF-21 is purified by proprietary chromatographic techniques. FGF21 (fibroblast growth factor) is a hormonal factor that belongs to the FGF superfamily. It is generated by the liver. The gene encoding FGF21 is localized on mouse chromosome 7.

Biochem/physiol Actions

FGF21 (fibroblast growth factor) controls glucose homeostasis and energy metabolism. It exhibits anti-diabetic properties by controlling glucose uptake in peripheral tissues. FGF21 also possesses autocrine effects in white adipose tissue. The protein is also involved in bone loss and exhibits hepatoprotective properties. In addition, FGF21 is also implicated in lipid metabolism and energy balance. It plays a key role in controlling oxidative stress cell response.

Physical form

Lyophilized from filtered (0.4 mm) solution containing 20 mM Tris, pH 7.4 and 20 mM NaCl

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile H?O to a concentration ? 100 μg/ml. This solution can then be diluted into other aqueous buffers.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Cell Culture Guide
Protocols & Articles

Articles

Fibroblast Growth Factor Family (FGF)

Fibroblast Growth Factors (FGFs) are potent regulators of cell proliferation, differentiation and function and are critically important in normal development, tissue maintenance, wound repair and ang...
Keywords: Angiogenesis, Cancer, Cardiovascular, Cell proliferation, Diabetes, Diseases, Gene expression, Growth factors, Ligands

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Peer-Reviewed Papers
15

References

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