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SRP6027 Sigma-Aldrich

UbcH5b human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym: UbcH

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Intracellular Protein Degradation, Nitric Oxide and Cell Stress, Ubiquitin and Proteases More...
biological source   human
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   liquid
mol wt   17.0 kDa
packaging   pkg of 10 μg
concentration   ~1.0 mg/mL
impurities   Endotoxin, tested
NCBI accession no.   P62837
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... UB2D2(7322)

Description

General description

E2 ubiquitin conjugating enzyme (UbcH5b), also called as ubiquitin conjugating enzyme E2D2 (UBE2D2), belongs to the active class of E2 ubiquitin conjugating enzymes, which also includes UbcH5A and UbcH5C. UbcH5b structure contains four N-terminal α-helices followed by four-stranded antiparallel β-sheet.

Biochem/physiol Actions

E2 ubiquitin conjugating enzyme (UbcH5b) is a vital component of E3 complex SCFβ-TrCP and it plays an important role in phospho-IκBα ubiquitination. UbcH5b along with others members of active classes of E2 enzymes plays a vital role in degradation of many regulatory and abnormal proteins, including important human transcription factors, such as p53, nuclear factor-κB (NF-κB) and c-Fos.

Physical form

Supplied at a concentration of 1.0 mg/ml in 20 mM Tris-HCl, pH 7.5, containing 0.5 mM DTT.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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