SRP6041 Sigma-Aldrich

IL-17A/F human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

Synonym: IL-17 A/F, IL17 A/F, Interleukin-17 A/F, Interleukin-17 AF



Related Categories Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones,
biological source   human
recombinant   expressed in E. coli
assay   ≥98% (SDS-PAGE)
form   lyophilized
mol wt   mol wt 30.7 kDa
packaging   pkg of 10 μg
impurities   Endotoxin, tested
NCBI accession no.   IL17A: Q16552
  IL17F: Q96PD4
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... IL17A(3605), IL17F(112744)


General description

Human IL-17A/F is a 40 kDa glycoprotein which is secreted as a disulfide-linked heterodimer. IL-17A/F consists of two proteins, IL-17A and IL17F. Human IL17A is produced as a 155 a.a precursor that includes a 23 amino acids signal sequence and a 132 amino acid chain that includes an N-linked glycosylation site. Human IL17F is produced as a 153 amino acid precursor with a 20 amino acid signal sequence and a 133 amino acid region and an N-linked glycosylation site. Both proteins (IL17A & IL17F) share 50 % amino acid sequence identity. Human IL17A & IL17F show approximately 60 % homology in their amino acid sequence to mouse IL-17A and IL-17F. Interleukin-17A/F and IL17A, IL17F homodimers are manufactured by activted CD4+ T cells, called Th17. IL-23 causes Th17 lymphocytes to manufacture IL-17A/F. Interleukin-17A/F induces chemokine production and airway neutrophilia with intermediate potency between IL17A (most potent) and IL17F (least potent). IL-17A/F Human Recombinant produced in E.Coli is a heterodimeric, non-glycosylated polypeptide chain containing 1 monomeric subunit of each IL-17A & IL-17F. The active dimer contains 271 amino acids and having a total molecular mass of 30.7 kDa. The IL-17A/F Human is purified by proprietary chromatographic techniques.


Centrifuge the vial prior to opening. Reconstitute with sterile H?O to a concentration not more than 1 mg/ml; This solution can then be diluted into other aqueous buffers.

Physical form

Lyophilized with no additives

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

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