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SRP6051 Sigma-Aldrich

RAGE human

recombinant, expressed in human cells, ≥95% (SDS-PAGE), ≥95% (HPLC)

Synonym: HDNF, NGF-2, NT-3, Neurotrophin-3, Receptor for advanced glycosylation end products

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Properties

biological source   human
recombinant   expressed in human cells
assay   ≥95% (HPLC)
  ≥95% (SDS-PAGE)
form   lyophilized
mol wt   ~35 kDa
packaging   pkg of 10 μg
NCBI accession no.   Q15109
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... AGER(117)

Description

General description

Advanced glycosylation end product-specific receptor, also known as receptor for advanced glycosylation end products, AGER and RAGE, belongs to the immunoglobulin superfamily of cell surface molecules. It lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Besides AGEs, AGER is also able to bind other ligands which is thought to result in pro-inflammatory gene activation. It is known that AGER serves as a mediator of both acute and chronic vascular inflammation in certain conditions such as atherosclerosis and in particular as a complication of diabetes. Furthermore, it plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.

Physical form

Lyophilized from a 0.2 μm filtered solution of 20 mM PB and 150 mM NaCl, pH7.2.

Preparation Note

Centrifuge the vial prior to opening.

Reconstitution

Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 μg/mL.). After adding 1x PBS, let the tube stand at room temperature for 3 minutes to allow lyophilized protein to dissolve. Mix the solution by inverting the tube 5 times. Centrifuge to pool sample.

Other Notes

Recombinant human AGER/RAGE produced by transfected human cell is a secreted protein with sequence (Ala23-Ala344) of human AGER/RAGE (Uniprot Entry: Q15109) fused with a poly-histidine tag at the C-terminus.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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