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SRP6058 Sigma-Aldrich

Kallikrein-3 human

recombinant, expressed in human cells, ≥95% (SDS-PAGE)

Synonym: APS, Hk3, KLK2A1, Kallikrein-3, P-30 antigen, PSA

  •  NACRES NA.32

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Properties

biological source   human
recombinant   expressed in human cells
assay   ≥95% (SDS-PAGE)
form   lyophilized
mol wt   35 kDa
packaging   pkg of 20 μg
NCBI accession no.   P07288
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... KLK3(354)

Description

General description

Prostate-specific antigen, also known as Gamma-seminoprotein, Kallikrein-3, kallikrein-related peptidase 3, Semenogelase, KLK3 and PSA, is a secreted protein which belongs to thepeptidase S1 family and Kallikrein subfamily. KLK3/Kallikrein 3 contains one peptidase S1 domain. KLK3/Kallikrein 3 is a glycoprotein produced almost exclusively by the prostate gland. KLK3/Kallikrein 3 is produced for the ejaculate where it liquifies the semen in the seminal coagulum and allows sperm to swim freely.It is also believed to be instrumental in dissolving the cervical mucous, allowing the entry of sperm. Human KLK3/Kallikrein 3 and human KLK2 are closely related products of the human kallikrein genes KLK3 and KLK2, respectively. Both KLK3/Kallikrein 3 and human kallikrein 2 are produced and secreted in the prostate and have important applications in the diagnosis of prostate cancer. Understanding the mechanism by which genetic variation in KLK3/Kallikrein 3 affects prostate cancer risk has important implications for study of the biological role of KLK3/Kallikrein 3 in prostate tumorigenesis.

Physical form

Lyophilized from sterile PBS, pH 7.4. (Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.)

Preparation Note

Centrifuge the vial prior to opening.

Reconstitution

Detailed reconstitution instructions are sent along with the product.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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