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SRP6086 Sigma-Aldrich

AKR7A2 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym: AFAR1, AFAR, AKR7, Aflatoxin B1 aldehyde reductase member 2, Aldo-keto reductase family 7 member A2

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Properties

biological source   human
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   liquid
mol wt   mol wt 44 kDa
packaging   pkg of 100 μg
NCBI accession no.   O43488 
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... AKR7A2(8574)

Description

General description

Aldo-keto reductases, such as AKR7A2, are involved in the detoxification of aldehydes and ketones. This protein can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the nonbinding AFB1 dialcohol. It may be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Also, it has been proposed previously to catalyze the NADPH-dependent reduction of succinic semialdehyde (SSA) to Gamma-Hydroxybutyrate in human brain.

Other Notes

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSELE LSAASRVVSR AAVHCALRSP PPEARALAMS RPPPPRVASV LGTMEMGRRM DAPASAAAVR AFLERGHTEL DTAFMYSDGQ SETILGGLGL GLGGGDCRVK IATKANPWDG KSLKPDSVRS QLETSLKRLQ CPQVDLFYLH APDHGTPVEE TLHACQRLHQ EGKFVELGLS NYASWEVAEI CTLCKSNGWI LPTVYQGMYN ATTRQVETEL FPCLRHFGLR FYAYNPLAGG LLTGKYKYED KDGKQPVGRF FGNSWAETYR NRFWKEHHFE AIALVEKALQ AAYGASAPSV TSAALRWMYH HSQLQGAHGD AVILGMSSLE QLEQNLAATE EGPLEPAVVD AFNQAWHLVA HECPNYFR

Preparation Note

Centrifuge the vial prior to opening.

Physical form

0.5 mg/mL solution in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 20% glycerol.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
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