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SRP6108 Sigma-Aldrich

Neuron-Specific Enolase human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym: 2-phospho-D-glycerate hydro-lyase, ENO2, Enolase 2, Gamma-enolase, NSE, Neural enolase

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Properties

biological source   human
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   liquid
mol wt   47 kDa (434 aa, 1-434 aa)
packaging   pkg of 100 μg
NCBI accession no.   P09104
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... ENO2(2026)

Description

General description

Enolase enzyme contains three subunits- α, β, and γ-and five isozymes namely αα, ββ γγ, αγ, and βγ. The isozymes that contain a γ subunit are expressed in neuronal and endocrine tissue and are known NSEs (neuron-specific enolases). NSE or γ-enolase is a highly soluble intracellular enzyme, which resides in cytoplasm, and shows predominant expression in neuronal tissues.

Biochem/physiol Actions

Enolases are responsible for catalyzing the catabolism of glycerol in the glycolytic pathway, and NSE catalyzes the conversion of 2-phosphoglycerate into phosphoenolpyruvate. NSE (neuron-specific enolase) is involved in the tumorigenesis of neuroendocrine origin tumors. Patients with multiple myeloma (MM) show elevated NSE serum levels, and these levels might help prognosticate efficiency of chemotherapy and disease progression. In diabetic patients the serum levels of NSE are higher than in normal subjects, and these levels are linked with peripheral neuropathy in diabetic patients. The serum levels of this protein are also elevated in patients with traumatic brain injury and neurodegenerative disease. In young adults, reduced hippocampal GM (gray matter) is related to increased NSE levels in obese individuals, suggesting an association between obesity with a specific marker of neuronal injury in a neurodegeneration and cognitive decline-sensitive brain area.

Physical form

1 mg/mL solution in 20 mM Tris-HCl (pH 7.5) containing 100 mM KCl and 5 mM MgSO4.

Preparation Note

Centrifuge the vial prior to opening.

Other Notes

MSIEKIWARE ILDSRGNPTV EVDLYTAKGL FRAAVPSGAS TGIYEALELR DGDKQRYLGK GVLKAVDHIN STIAPALISS GLSVVEQEKL DNLMLELDGT ENKSKFGANA ILGVSLAVCK AGAAERELPL YRHIAQLAGN SDLILPVPAF NVINGGSHAG NKLAMQEFMI LPVGAESFRD AMRLGAEVYH TLKGVIKDKY GKDATNVGDE GGFAPNILEN SEALELVKEA IDKAGYTEKI VIGMDVAASE FYRDGKYDLD FKSPTDPSRY ITGDQLGALY QDFVRDYPVV SIEDPFDQDD WAAWSKFTAN VGIQIVGDDL TVTNPKRIER AVEEKACNCL LLKVNQIGSV TEAIQACKLA QENGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR SERLAKYNQL MRIEEELGDE ARFAGHNFRN PSVL

Safety & Documentation

Safety Information

Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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