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SRP6157 Sigma-Aldrich

BMP-7 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Synonym: Bone morphogenetic protein 7, Eptotermin alfa, OP1, Osteogenic protein 1

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Properties

Related Categories Cell Culture, Growth Factors and Cytokines, Reagents and Supplements, Recombinant Bone Morphogenetic Proteins (BMP), Transforming Growth Factors More...
biological source   human
recombinant   expressed in HEK 293 cells
assay   ≥95% (SDS-PAGE)
form   lyophilized
mol wt   mol wt 30-38 kDa (homodimer, glycosylated)
packaging   pkg of 10 μg
NCBI accession no.   P18075
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... BMP7(655)

Description

Preparation Note

Centrifuge the vial prior to opening.

Reconstitution

Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.

Physical form

Lyophilized from a solution of 50 mM sodium acetate, pH 4.5, with 50 mM NaCl.

Biochem/physiol Actions

As implied by their name, bone morphogenetic proteins (BMPs) promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. Based on its expression early in embryogenesis, BMP-7 has a proposed role in early development. In addition, the fact that BMP-7 is closely related to BMP5 has led to speculation of possible bone inductive activity. BMP-7 induces apoptosis in B-cells. It has a role in organ development and may have a role in liver regeneration. Mutations in the gene encoding the protein have been shown to affect the development of teeth, palate and other orofacial complexes.

General description

Bone morphogenetic protein-7 (BMP-7) belongs to the transforming growth factor-β (TGF-β) superfamily. The gene encoding it is localized on human chromosome 20q13.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


Request a Serum Sample

Cell Culture Guide
Protocols & Articles

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Peer-Reviewed Papers
15

References

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