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SRP6159 Sigma-Aldrich

FGF-basic human

recombinant, expressed in human cells, ≥95% (SDS-PAGE)

Synonym: FGF-2, FGF-b, HBGF-2, HBGH-2, Prostatropin

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Properties

Related Categories Cell Culture, FGF-2 (FGF basic), Fibroblast Growth Factors (FGF), Growth Factors and Cytokines, Reagents and Supplements More...
biological source   human
recombinant   expressed in human cells
assay   ≥95% (SDS-PAGE)
form   lyophilized
mol wt   mol wt 17 kDa (monomer, non-glycosylated)
packaging   pkg of 10 μg
NCBI accession no.   P09038
UniProt accession no.   P09038
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... FGF2(2247)

Description

Preparation Note

Centrifuge the vial prior to opening.

Reconstitution

Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.

Physical form

Lyophilized from a PBS solution.

Biochem/physiol Actions

FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. The protein associates with fibroblast growth factor receptors 1, 2 and 3 (FGFR-1, -2, -3).

General description

FGF-basic is a member of the fibroblast growth factor (FGF) family. Three alternatively spliced variants encoding different isoforms have been described. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors. The gene encoding this protein is localized on human chromosome 4q28.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


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Cell Culture Guide
Protocols & Articles

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Peer-Reviewed Papers
15

References

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