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SRP6162 Sigma-Aldrich

FGF-8b human

recombinant, expressed in human cells, ≥95% (SDS-PAGE)

Synonym: AIGF, FGF-17a, Fibroblast growth factor 17a, Fibroblast growth factor 8b, HBGF-8

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Properties

Related Categories Cell Culture, FGF-4 to FGF-8, Fibroblast Growth Factors (FGF), Growth Factors and Cytokines, Reagents and Supplements More...
biological source   human
recombinant   expressed in human cells
assay   ≥95% (SDS-PAGE)
form   lyophilized
mol wt   30-45 kDa (monomer, glycosylated)
packaging   pkg of 10 μg
NCBI accession no.   P55075
UniProt accession no.   P55075
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... FGF8(2253)

Description

General description

FGF8 (fibroblast growth factor 8) is mapped to human chromosome 10q24.32. It is a part of the fibroblast growth factor family. In adults, the FGF8 gene is expressed only in testis. During development, FGF8a and FGF8b isoforms are expressed in midbrain and hindbrain.

Biochem/physiol Actions

FGF8 (fibroblast growth factor 8) gene encodes secreted signaling molecules, which is essential for the formation of face, brain and limbs, during development. Overexpression of FGF8 is observed in hepatocellular carcinoma and also offers resistance to chemotherapy. FGF family members have wide mitogenic and cell survival activities and participate in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF8 supports androgen and anchorage independent growth of mammary tumor cells. FGF8 over expression increases tumor growth and angiogensis. The adult expression of FGF-8 gene is restricted to testes and ovaries. FGF8 functions as an embryonic epithelial factor. FGF8 takes part in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination.

Physical form

Lyophilized in solution of 10 mM Tris-HCl, pH 7.4, with 800 mM NaCl

Preparation Note

Centrifuge the vial prior to opening.

Reconstitution

Reconstitute in sterile water containing 0.1% endotoxin-free recombinant human serum albumin.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Cell Culture Guide
Protocols & Articles

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Peer-Reviewed Papers
15

References

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