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SRP6170 Sigma-Aldrich

IL-2 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Synonym: Aldesleukin, Lymphokine, N/A, T-cell growth factor (TCGF)

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Properties

Related Categories Cell Culture, Growth Factors and Cytokines, Interleukin-2, Interleukins (IL), Reagents and Supplements More...
biological source   human
recombinant   expressed in HEK 293 cells
assay   ≥95% (SDS-PAGE)
form   lyophilized
potency   0.2-2 ng/mL
mol wt   15 kDa (monomer, glycosylated)
packaging   pkg of 10 μg
NCBI accession no.   P60568
UniProt accession no.   P60568
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... IL2(3558)

Description

General description

IL-2 (interleukin 2) is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. It is a type I cytokine. Recombinant human IL-2 is a 15.5kDa protein, containing 134 amino acid residues including one intrachain disulfide bond.

The IL-2 gene is mapped to human chromosome 4q27.

Application

IL-2 (interleukin 2) human has been used for the stimulation of human primary naive T lymphocytes to study the effect of microRNA-146a on IL-2 activation-induced cell death.

Biochem/physiol Actions

IL-2/IL-2R (interleukin 2/IL-2 receptor) signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK (natural killer) cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. It is associated with recurrent oral ulcer and asthma and Mycoplasma pneumoniae infection in children. Absence of IL-2 in mice causes fatal lymphoproliferative inflammatory disease (IL-2 deficiency syndrome). IL-2 signaling involves three pathways: phosphoinositol 3-kinase (PI3-K)/AKT, Ras-MAPK (mitogen activated protein kinase), and JAK-STAT (Janus kinase - signal transducers and activators of transcription) pathways.

Physical form

Lyophilized from a PBS solution.

Preparation Note

Centrifuge the vial prior to opening.

Reconstitution

Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Peer-Reviewed Papers
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References

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