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SRP6172 Sigma-Aldrich

IL-4 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Synonym: B-cell stimulatory factor 1 (BSF-1), BCGF, Binetrakin, Lymphocyte stimulatory factor 1, Pitrakinra

  •  NACRES NA.32

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Properties

Related Categories Cell Culture, Growth Factors and Cytokines, Interleukin-4, Interleukins (IL), Reagents and Supplements More...
biological source   human
recombinant   expressed in HEK 293 cells
assay   ≥95% (SDS-PAGE)
form   lyophilized
mol wt   (14 and 19 kDa, monomer)
packaging   pkg of 10 μg
NCBI accession no.   P05112
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... IL4(3565)

Description

General description

Interleukin-4 (IL-4) is a pleiotropic cytokine and a potent lymphoid cell growth factor. It is produced by activated T cells and is a ligand for interleukin 4 receptor. The gene encoding this protein is localized on human chromosome 5q31.1. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Biochem/physiol Actions

Interleukin-4 (IL-4) stimulates the growth and survivability of certain B cells and T cells. The interleukin 4 receptor also binds to interleukin-13 (IL-13), which may contribute to many overlapping functions of this cytokine and IL-13. STAT6 (signal transducer and activator of transcription-6) has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This protein exhibits anti-inflammatory responses and has a role in immune processes by protecting against intracellular pathogens.

Physical form

Lyophilized from a solution of 20 mM Tris-HCl, pH 7.4, with 300 mM NaCl.

Preparation Note

Centrifuge the vial prior to opening.

Reconstitution

Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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