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SRP6324 Sigma-Aldrich

CD1E human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

Synonym: CD1A, R2, T-cell surface glycoprotein CD1e

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Properties

Related Categories CD1 to CD48, Cell Biology, Cell Signaling and Neuroscience, Cluster of Differentiation (CD) Proteins, Cytokines and Growth Factors,
biological source   human
recombinant   expressed in E. coli
assay   ≥85% (SDS-PAGE)
form   liquid
mol wt   33.1 kDa (297 aa, 32-305 aa + His tag)
packaging   pkg of 100 μg
concentration   1 mg/mL
impurities   <1 EU/μg endotoxin (LAL test)
UniProt accession no.   P15812
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... CD1E(913)

Description

General description

CD1E is a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with β-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. CD1E localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Recombinant human CD1E protein, fused to His-tag at N-terminus, was expressed in E.coli.

Physical form

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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