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SRP6376 Sigma-Aldrich

CD273 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Synonym: Butyrophilin B7-DC, PDCD1 ligand 2, PDCD1L2, PDCD1LG2, PDL2

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Properties

Related Categories CD160 to CD340, Cell Biology, Cell Signaling and Neuroscience, Cluster of Differentiation (CD) Proteins, Cytokines and Growth Factors,
biological source   human
recombinant   expressed in HEK 293 cells
assay   ≥95% (SDS-PAGE)
form   lyophilized
mol wt   calculated mol wt 23.4 kDa
  observed mol wt 35-48 kDa (DTT-reduced. Protein migrates due to glycosylation. Leu 20 is the predicted N-terminus.)
packaging   pkg of 10 μg
  pkg of 50 μg
conjugate   6-His tagged (C-terminus)
UniProt accession no.   Q9BQ51
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... PDCD1LG2(80380)

Description

General description

Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as butyrophilin B7-DC or CD antigen CD273. It belongs to the immunoglobulin superfamily or BTN/MOG family. The gene encoding CD273 is localized on human chromosome 9p24.1.

Biochem/physiol Actions

The expression of programmed cell death 1 ligand 2 (PD-L2) or CD antigen 273 (CD273) is up-regulated by interferon-γ (IFNG/IFN-γ) stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with colony-stimulating factor-2 (CSF2) and interleukin-4 (IL-4). PD-L2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

Physical form

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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