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SRP6411 Sigma-Aldrich

BRD1 (556-688) his tag human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym: BR140-like protein, BRPF1, BRPF2, Bromodomain & PHD finger-containing protein 2, Bromodomain containing 1, DKFZp686F0325

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Properties

biological source   human
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   liquid
mol wt   17.8 kDa (156 aa, 556-688 aa + His Tag)
packaging   pkg of 100 μg
concentration   0.5 mg/mL
UniProt accession no.   O95696
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... BRD1(23774)

Description

General description

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BRD1 is a bromodomain containing protein that has been identified as a susceptibility gene in neurological disorders, such as schizophrenia and bipolar affective disorder. This protein can be used for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling. Recombinant human BRD1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Physical form

0.5 mg/mL in Phosphate buffer saline (pH 7.4) containing 10% glycerol and 1mM DTT.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

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Protocols & Articles
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