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SRP6504 Sigma-Aldrich

Notch-2 from mouse

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym: Neurogenic Locus Notch Homolog Protein 2, Notch B

  •  NACRES NA.32

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Properties

biological source   mouse
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   lyophilized
mol wt   calculated mol wt ~87 kDa (The extracellular domain of mouse Notch-2 (aa 26-494) (12 epidermal growth factor-like (EGF) repeats))
packaging   pkg of 25 μg
impurities   <0.01 EU/μg endotoxin (LAL test)
UniProt accession no.   O35516
shipped in   wet ice
storage temp.   −20°C
Gene Information   mouse ... NOTCH2(18129)

Description

General description

Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.

Physical form

Lyophilized with PBS.

Reconstitution

Reconstitute with sterile water to 1 mg/mL.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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