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SRP6523 Sigma-Aldrich

ApoJ/Clusterin from mouse

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym: AAG4, Apolipoprotein J, CLI, CLU, KUB1, MGC24903, SGP-2, SGP2, TRPM-2, TRPM2

  •  NACRES NA.32

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Properties

biological source   mouse
recombinant   expressed in E. coli
assay   ≥90% (SDS-PAGE)
form   liquid
mol wt   ~45 kDa (Mouse nuclear Clusterin aa 22- 448 is fused at the C-terminus to a His-tag.)
packaging   pkg of 10 μg
  pkg of 50 μg
concentration   1 mg/mL
impurities   <1 EU/μg endotoxin (LAL test)
UniProt accession no.   Q06890
shipped in   wet ice
storage temp.   −20°C
Gene Information   mouse ... CLU(12759)

Description

General description

Native Apolipoprotein J (ApoJ), also named Clusterin, is a heavily glycosylated, 75-80 kDa disulfide-linked heterodimeric protein. Despite being cloned since 1989, no genuine function has been attributed to ApoJ so far. The protein has been reportedly implicated in several diverse physiological processes such as sperm maturation, lipid transportation, complement inhibition, tissue remodeling, membrane recycling, cell-cell and cell-substratum interactions, stabilization of stressed proteins in a folding-competent state and promotion or inhibition of apoptosis. ApoJ gene is differentially regulated by cytokines, growth factors and stress-inducing agents. Clusterin is up- or down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others.

Physical form

1 mg/mL of 0.2 μm-filtered solution in 55 mM Tris-Cl, pH 8.2, containing 150 mM NaCl.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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