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SRP6572 Sigma-Aldrich

BRM (1367-1511) GST tag human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym: SMARCA2A/B, SWI/SNF ATPase

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Properties

biological source   human
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   liquid
mol wt   43.7 kDa (1367-1511 aa + NT GST Tag)
packaging   pkg of 100 μg
  pkg of 20 μg
UniProt accession no.   P51531
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... SMARCA2(6595)

Description

General description

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BRM is a member of the SWI/SNF protein family, which forms part of a large ATP-dependent chromatin remodeling complex. This complex is required for transcriptional activation of genes normally repressed by chromatin.

Physical form

50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

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