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SRP8003 Sigma-Aldrich

Clusterin (nuclear form) mouse

recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)

Synonym: Apolipoprotein J, CLI, Lymphocyte antigen 52 (Ly-52), SGP-2, TRPM-2

  •  NACRES NA.32

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Properties

Related Categories Apoptosis Inhibitors, Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience
biological source   mouse
recombinant   expressed in E. coli
assay   >90% (SDS-PAGE)
form   liquid
mol wt   ~45 kDa by SDS-PAGE
packaging   pkg of 50 μg
storage condition   avoid repeated freeze/thaw cycles
concentration   ≥0.2 mg/mL
impurities   <1 EU/μg endotoxin, tested
color   clear
conjugate   His tagged
UniProt accession no.   Q06890
shipped in   wet ice
storage temp.   −20°C
Gene Information   mouse ... Clu(12759)

Description

General description

Clusterin is expressed in all tissues. However, it is strongly expressed in the central nervous system and plasma. Clusterin mainly protects against heat and other stress. It is also referred as chaperone protein and stress-inducible biomarker. Clusterin exists in two isoforms, one is a secretory form and other is a nuclear form. The secreted form of the protein is a 80kDa disulfide-linked heterodimer of α and β subunits (produced by internal cleavage). The alternatively spliced inactive cytosolic form is changed to a truncated mature nuclear isoform via ionizing irradiation.

Biochem/physiol Actions

Clusterin is involved in tissue remodeling, cell death, lipid transport, complement-associated cell lysis, cancer and neurological damage. It is strongly expressed in Alzheimer’s and treatment-resistant cancer. High levels of clusterin are observed in ischemic heart disease and diabetic conditions. It also protects kidney from fibrosis. Nuclear form of clusterin works as a pro-death signal, and suppresses cell growth and survival. The secreted form of clusterin has extracellular chaperone and anti-apoptotic activities.

Physical form

Solution in 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl.

Other Notes

Mouse nuclear clusterin (aa 22-448) is fused at the C-terminus to a His-tag.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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