• USA Home
  • SRP8004 - Clusterin (secretory form) human

EMAIL THIS PAGE TO A FRIEND
SRP8004 Sigma-Aldrich

Clusterin (secretory form) human

recombinant, expressed in HEK 293 cells, FLAG® tagged, >90% (SDS-PAGE)

Synonym: Apolipoprotein J, CD223, CLI, SGP-2, TRPM-2

Purchase

Properties

Related Categories Apoptosis Inhibitors, Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience
biological source   human
recombinant   expressed in HEK 293 cells
assay   >90% (SDS-PAGE)
form   liquid
mol wt   76-80 kDa by SDS-PAGE
packaging   pkg of 10 μg
storage condition   avoid repeated freeze/thaw cycles
concentration   ≥0.2 mg/mL
application(s)   immunoblotting: suitable
impurities   <0.1 EU/μg endotoxin, tested
color   clear
conjugate   FLAG® tagged
UniProt accession no.   P10909
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... CLU(1191)

Description

General description

Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80-kDa disulfide-linked heterodimer of alpha and beta subunits (produced by internal cleavage). Clusterin is expressed in virtually all tissues and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. Clusterin also exists as a nuclear protein. The secreted form of Clusterin has extracellular chaperone and anti-apoptotic activities while the nuclear form acts as a proapoptotic factor.

Physical form

Solution in PBS, pH 7.2.

Other Notes

Signal peptide sequence and the human secretory clusterin (aa 1-449) are fused at the C-terminus to a FLAG®-tag.

Legal Information

FLAG is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number

Request a Serum Sample
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?