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SRP8010 Sigma-Aldrich

GPX1 human

recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)

Synonym: Cellular glutathione peroxidase, Death receptor 6, GSHPx-1, Glutathione peroxidase 1

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Nitric Oxide and Cell Stress, Oxidative Stress Enzymes,
biological source   human
recombinant   expressed in E. coli
assay   >90% (SDS-PAGE)
form   lyophilized
mol wt   ~25 kDa by SDS-PAGE
packaging   pkg of 10 μg
storage condition   avoid repeated freeze/thaw cycles
impurities   <1 EU/μg endotoxin, tested
color   white
conjugate   His tagged
UniProt accession no.   P07203
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... GPX1(2876)

Description

General description

GPX1 (glutathione peroxidase 1) is a selenoprotein and the gene is mapped to human chromosome 3p21.3. It is present in the cytoplasm and is widely expressed.

Biochem/physiol Actions

GPX1 (glutathione peroxidase 1) is responsible for scavenging free radicals and derivatives. GPXs reduces lipid hydroperoxides to the corresponding alcohols as well as free hydrogen peroxide to water. Mutations in the GPX1 gene are associated with nonalcoholic fatty liver disease (NAFLD) susceptibility. Mutation in GPX1 at C594T is linked with oxidative stress-associated disorders, including prostate cancer and bladder cancer.

Physical form

Lyophilized from 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl, 1 mM DTT.

Reconstitution

Reconstitute with 100 μL deionized water.

Other Notes

Human GPX1 (aa 1-201) is fused at the C-terminus to a His-tag.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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