EMAIL THIS PAGE TO A FRIEND
SRP8026 Sigma-Aldrich

Annexin V human

recombinant, expressed in E. coli, GST tagged, ≥95% (SDS-PAGE)

Synonym: Annexin A5, Calphobindin I, EC 2.7.1.23, Endonexin II, Placental anticoagulantprotein I

  •  NACRES NA.32

Purchase

Properties

biological source   human
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   lyophilized
mol wt   ~52 kDa
packaging   pkg of 100 μg
storage condition   avoid repeated freeze/thaw cycles
application(s)   activity assay: suitable
color   white
conjugate   GST tagged
UniProt accession no.   P08758
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... ANXA5(308)

Description

General description

Annexin V is a member of the annexin family of calcium and membrane-binding proteins that have anticoagulatory and anti-inflammatory properties. The encoded protein is 320 amino acid long and is folded into four domains, each having five α-helices, forming a superhelical globular structure. The ANX5 gene is mapped to human chromosome 4q26-q28 and spans a length of 28kb containing 13 exons and 12 introns.

Application

Annexin V has been used to examine phosphorylation activity of ChaK1 (channel-kinase 1).

Biochem/physiol Actions

Annexins are a family of water-soluble proteins that bind to membranes and phospholipids in a calcium-dependent manner. They participate in several cellular functions, such as membrane fusion and cytoskeletal interaction. Annexin V is a potent anticoagulant and serves as a voltage-gated calcium channel when bound to membrane in vitro. It is found to inhibit phospholipase A2 and protein kinase C.

Physical form

Lyophilized from PBS, pH 7.4.

Reconstitution

Reconstitute with 100 μL deionized water.

Other Notes

Recombinant human annexin V fused to a GST-tag.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number

Request a Serum Sample
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?