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SRP8030 Sigma-Aldrich

Fn14 (human): FC (human)

recombinant, expressed in HEK 293 cells, >95% (SDS-PAGE)

Synonym: CD266, E1A-associated protein p300, FGF-inducible 14, Tumor necrosis factor receptor superfamily member 12A

  •  NACRES NA.32

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Properties

biological source   human
recombinant   expressed in HEK 293 cells
assay   >95% (SDS-PAGE)
form   lyophilized
mol wt   ~35 kDa by SDS-PAGE
packaging   pkg of 50 μg
storage condition   avoid repeated freeze/thaw cycles
impurities   <0.1 EU/μg endotoxin, tested
color   white
UniProt accession no.   Q9NP84
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... TNFRSF12A(51330)

Description

General description

TWEAK is a cytokine that controls proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK binds to Fn14, a highly inducible cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-B (NF-kappaB) pathway. The TWEAK-Fn14 axis plays a beneficial role in tissue repair following acute injury and may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke.

Physical form

Lyophilized from PBS.

Reconstitution

Reconstitute with 50 μL deionized water.

Other Notes

The extracellular region of human FN14 (aa 28-75) is fused at the C-terminus to the Fc portion of human IgG1.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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