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SRP8046 Sigma-Aldrich

Netrin-1 (human): FC (human)

recombinant, expressed in HEK 293 cells, >95% (SDS-PAGE)

Synonym: ACRP30headless:TNFSF13, NTN1

  •  NACRES NA.32

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Properties

biological source   human
recombinant   expressed in HEK 293 cells
assay   >95% (SDS-PAGE)
form   lyophilized
mol wt   ~90 kDa by SDS-PAGE
packaging   pkg of 10 μg
storage condition   avoid repeated freeze/thaw cycles
impurities   <0.1 EU/μg endotoxin, tested
color   white
UniProt accession no.   O95631
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... NTN1(9423)

Description

General description

Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin 1 is also Involved in tumorigenesis by regulating apoptosis.

Physical form

Lyophilized from PBS with trehalose and Brij35.

Reconstitution

Reconstitute with 100 μL deionized water.

Other Notes

Human netrin-1 (aa 25-604) is fused at the C-terminus to the Fc portion of human IgG1.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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