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SRP8052 Sigma-Aldrich

CD279 (human): FC (human)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

Synonym: Hepatitis A virus cellular receptor 2, PD-1, Programmed cell death protein 1

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Properties

Related Categories CD160 to CD340, Cell Biology, Cell Signaling and Neuroscience, Cluster of Differentiation (CD) Proteins, Cytokines and Growth Factors,
biological source   human
recombinant   expressed in CHO cells
assay   ≥98% (SDS-PAGE)
form   lyophilized
mol wt   monomer 46 kDa by calculation
packaging   pkg of 100 μg
impurities   <0.06 EU/μg endotoxin, tested
UniProt accession no.   Q15116
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... PDCD1(5133)

Description

General description

Programmed Death-1 (PD-1, CD279) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T-cells, B-cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-γ. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.

Physical form

Lyophilized from 0.2 μm-filtered solution in PBS.

Reconstitution

Reconstitute at 100 μg/mL in sterile PBS.

Other Notes

The extracellular domain of human CD279 [PD-1] (aa 25-167) is fused to the N-terminus of the Fc region of human IgG1.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

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