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  • T0442 - Anti-phospho-Tyk2 (pTyr1054/1055) antibody produced in rabbit

T0442 Sigma

Anti-phospho-Tyk2 (pTyr1054/1055) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, Antibodies to Phosphoproteins at Phosphotyrosine (pTyr),
species reactivity   human
application(s)   western blot: 1:1000
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous glycerol solution
mol wt   mol wt 134 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... TYK2(7297)
biological source   rabbit
conjugate   unconjugated
UniProt accession no.   P29597



synthetic phospho-Tyr1054/1055 peptide corresponding to residues around Tyr1054/1055 of human Tyk2.

General description

Tyk2 is a member of the Jak family of protein tyrosine kinases. It associates with and is activated by
receptors for many cytokines including IL-13, the IL-6 family, IL-10, and IFN-a and β. Following ligand binding,
Tyk2 is activated by phosphorylation of Tyr1054 and/or Tyr1055. Tyk2 is required for the tyrosine phosphoryla-
tion of Stat3 in the IFN-β signaling cascade.

Physical form

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol


Detects human Tyk2 only when phosphorylated at Tyr1054/1055.

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WGK Germany  2
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Antibody Basics

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Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
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