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T0452 Sigma-Aldrich

D-α-Tocotrienol

from rice, ≥75% (GC)

Synonym: 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2H-1-benzopyran-6-ol

  • CAS Number 1721-51-3

  • Empirical Formula (Hill Notation) C29H44O2

  • Molecular Weight 424.66

  •  NACRES NA.79

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Properties

Related Categories Antioxidant, Cell Biology, Functional Foods, Nutrition Research
Quality Level   200
biological source   rice
assay   ≥75% (GC)
form   liquid
color   colorless to brown
mp   30-31 °C
storage temp.   −20°C
InChI   1S/C29H44O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h12,14,16,30H,9-11,13,15,17-19H2,1-8H3/b21-14+,22-16+/t29-/m1/s1
InChI key   RZFHLOLGZPDCHJ-XZXLULOTSA-N

Description

General description

Tocotrienols belong to the vitamin E family and have an unsaturated isoprenoid side chain. The various isoforms of tocotrienols differ in their methyl substitution in the chromanol head. α-Tocotrienol present in crude palm oil is regarded as a natural supplement.

Biochem/physiol Actions

α-Tocotrienol may be used along with other isoforms to differentiate tocotrienol activities.

α-Tocotrienol is an effective free radical scavengerand elicits protective functionality during oxidative stress in microsomes. It is a strong antioxidant, which reduces inflammation and is used in cancer treatment. α-tocotrienol supplementation may reduce cholesterol levels in hypercholesterolemia. α-tocotrienol is neuroprotective as it blocks glutamate-induced cell death in neuronal cells.

Tocotrienols are widely utilized for their strong antioxidant properties. The various isoforms of tocotrienols differ in their methyl substitution in the chromanol head. α-tocotrienol demonstrates neuroprotective properties by blocking glutamate-induced cell death in neuronal cells.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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