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T0578 Sigma-Aldrich

Teicoplanin

Synonym: Targocid, Teichomycin

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Mechanism of Action,
assay   ≥80% (teicoplanins A2, HPLC)
form   powder
color   white to faint beige
  white to faint yellow
  white to light brown
solubility   H2O: soluble 10 mg/mL
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   Gram-positive bacteria
storage temp.   2-8°C

Description

Application

Teicoplanin is a glycopeptide antibiotic produced by Actinoplanes teichomiceticus that is effective against Gram-positive bacteria resistant to β-lactam antibiotics. Teicoplanin and vancomycin have been used clinically for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. Product T0578 is a mixture of six primary teicoplanins; primarily teicoplanins A2 group.

Biochem/physiol Actions

Teicoplanin is a glycopeptide antibiotic. It is a mixture of several compounds, five major (named teicoplanin A2-1 through A2-5) and four minor (named teicoplanin RS-1 through RS-4). All teicoplanins share a same glycopeptide core, termed teicoplanin A3-1, a fused ring structure to which two carbohydrates (mannose and N-acetylglucosamine) are attached. The major and minor components also contain a third carbohydrate moiety, β-D-glucosamine, and differ only by the length and conformation of a side chain attached to it. It′s mechanism of action is through inhibition of bacterial cell wall biosynthesis.

Teicoplanin is a glycopeptide antibiotic produced by Actinoplanes teichomiceticus that is effective against Gram-positive bacteria resistant to β-lactam antibiotics. Its mechanism of action is through inhibition of bacterial cell wall biosynthesis. Teicoplanin and vancomycin have been used clinically for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections.

Packaging

100MG,1G

Other Notes

Mixture of six primary teicoplanins; primarily teicoplanins A2 group.

Keep container tightly closed in a dry and well-ventilated place.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
WY1559000

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles
Peer-Reviewed Papers
15

References

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