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T0632 Sigma-Aldrich

Sodium thioglycolate

≥96.5% (iodometric)

Synonym: Mercaptoacetic acid sodium salt, Thioglycolic acid sodium salt

  • CAS Number 367-51-1

  • Linear Formula HSCH2COONa

  • Molecular Weight 114.10

  •  Beilstein/REAXYS Number 4569109

  •  EC Number 206-696-4

  •  MDL number MFCD00043386

  •  PubChem Substance ID 24899901

  •  NACRES NA.25

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Properties

Related Categories Biochemicals and Reagents, Carbohydrates, Carbohydrates A to Z, Carbohydrates P-Z, Monosaccharide More...
Quality Level   200
assay   ≥96.5% (iodometric)
mp   >300 °C (lit.)
storage temp.   −20°C
SMILES string   [Na+].[O-]C(=O)CS
InChI   1S/C2H4O2S.Na/c3-2(4)1-5;/h5H,1H2,(H,3,4);/q;+1/p-1
InChI key   GNBVPFITFYNRCN-UHFFFAOYSA-M

Description

Application

Sodium thioglycolate has been used:
• as a growth supplement in enrichment media and to study its effect on Arcobacter
• in influenza hemagglutinin formulation in order to reduce disulfide-mediated cross-linking and early potency loss
• in electron microscopy

Packaging

25, 100, 500 g in poly bottle

Biochem/physiol Actions

Sodium thioglycolate acts as reducing agent and is suitable for anaerobic and microaerophilic bacterial growth.

Sodium thioglycolate is a commonly used reagent for bacteriological research to maintain reducing conditions in media. Thioglycolate can also protect enzymes against inactivation by maintaining protein thiol groups in the reduced state. Thioglycolate medium is frequently used in inflammation research to elicit a neutrophil and macrophage response in vivo.

Caution

At room temperature, concentrations over 70% in water tend to form 1-2% thioglycolides per month which hydrolyze to the original free compound when made acidic or alkaline. The 70% solution oxidizes in air but is stable at room temperature when tightly closed. Thioglycolate salts may also lose purity on storage. The exclusion of air does not materially improve stability.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Personal Protective Equipment 
RIDADR 
UN 3335
WGK Germany 
WGK 1
RTECS 
AI7700000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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