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  • T0678 - Monoclonal Anti-Tryptophan Hydroxylase antibody produced in mouse

T0678 Sigma

Monoclonal Anti-Tryptophan Hydroxylase antibody produced in mouse

clone WH-3, ascites fluid



Related Categories Alphabetical Index, Antibodies, Antibodies for Neurobiology, Antibodies for Neurotransmission, Antibodies for Neurotransmitter Synthesis and Metabolism,
species reactivity   rabbit, rat, human, monkey
application(s)   immunohistochemistry: suitable
  indirect ELISA: suitable
  microarray: suitable
  western blot: 1:1,000 using rabbit pineal gland extract
clone   WH-3, monoclonal
antibody form   ascites fluid
isotype   IgG3
mol wt   antigen mol wt 55 kDa
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... TPH1(7166), TPH2(121278)
rat ... Tph1(24848), Tph2(317675)
biological source   mouse
conjugate   unconjugated



recombinant rabbit tryptophan hydroxylase.

General description

The tryptophan hydroxylase 1 gene (TPH1) is a 444 amino acid protein encoded by the gene spanning 29 kbp with11 exons on human chromosome 11p15.3-p14. The enzyme is expressed in the gut, spleen, thymus, pituitary and also in the pineal gland.


This antibody reacts specifically with tryptophan hydroxylase.


Monoclonal Anti-Tryptophan Hydroxylase antibody produced in mouse has been used in immunohistochemistry and immunoblotting.

Biochem/physiol Actions

The tryptophan hydroxylase 1 gene (TPH1) catalyzes the synthesis of 5-hydroxytryptophan, which is a precursor to the neurotransmitter serotonin. Variation in the gene expression affects prefrontal cortex activation during response inhibition. Mutation in the TPH1 gene leads to schizophrenia, irritable bowel syndrome (IBS) in women, suicidal behavior and depressive disorders. The encoded protein plays a vital role in regulation of cardiovascular function.

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RIDADR  NONH for all modes of transport
WGK Germany  nwg
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Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
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