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T1126 Sigma

Thyroglobulin from porcine thyroid gland




Related Categories Application Index, Biochemicals and Reagents, Enzymes, Inhibitors, and Substrates, Plasma & Blood Proteins, Plasma, Blood, and Related Proteins and Reagents,
form   powder
mol wt   mol wt ~670 kDa
composition   Iodine, ≥0.3%
nitrogen analysis   14.0-17.5% total
ash   ≤4%
isoelectric point   4.58
storage temp.   −20°C


Other Notes

Electrophoretically heterogeneous.


1 g in poly bottle

100, 500 mg in poly bottle

Preparation Note

When reconstituted in water (20 mg/ml), a turbid solution with some insolubles is observed.

Biochem/physiol Actions

Thyroglobulin has been shown to regulate the transcription of iodide porters including sodium iodide symporter and pendrin.

Thyroglobulin is a major protein involved with iodine metabolism. It consists of an iodine-containing protein that is stored in the thyroid gland and is converted into circulating thyroxines when the thyroid is stimulated by TSH (Thyroid Stimulating Hormone) from the pituitary. Thyroglobulin is often used as a carrier protein for the production of antibodies. Its advantage as a carrier protein comes from its large number of tyrosine residues that can be used for conjugation using the diazo reaction.

Price and Availability

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Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles


A Validated Amino Acid Analysis Assay for Accurate Quantification of Stable Isotope Labeled Protein Reference Materials: SIL Thyroglobulin Case Study

With the emergence of mass spectrometry for the clinical measurement of proteins in biological matrices, the development of biological reference materials will continue to grow in importance. Certifi...
Kevin Ray1, Pegah R. Jalili1, Mark Angeles1, James J. Walters1, Isil Dilek2, and Uma Sreenivasan2

1 - MilliporeSigma, St. Louis, MO
2 - MilliporeSigma, Round Rock, TX
Keywords: Amino acid analysis, Clinical, Fractionation, High performance liquid chromatography, Mass spectrometry, PAGE, Protein extraction

Characterization of Clinically-Relevant Stable Isotope Labeled Recombinant Proteins For Use As Internal Standards in Quantitative MS Workflows

Methods for quantification of clinical protein biomarkers by mass spectrometry demand a high level of analytical quality. Procedures must be developed to minimize and control experimental variations ...
Kevin Ray, Pegah Jalili, James Walters, David Rhee
Sigma-Aldrich, St. Louis, MO
Keywords: Clinical, Fractionation, Mass spectrometry, Protein extraction

Plasma Derived Proteins and Enzymes

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Applications, Gas chromatography, Type

Peer-Reviewed Papers


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