• USA Home
  • T123 - Thioperamide maleate salt

EMAIL THIS PAGE TO A FRIEND
T123 Sigma-Aldrich

Thioperamide maleate salt

solid

Synonym: MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt

  • CAS Number 148440-81-7

  • Empirical Formula (Hill Notation) C15H24N4S · C4H4O4

  • Molecular Weight 408.52

  •  MDL number MFCD00083209

  •  PubChem Substance ID 24277809

  •  NACRES NA.77

Purchase

Properties

Related Categories Antagonists- Histaminergics, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
assay   ≥98% (HPLC)
form   solid
storage condition   desiccated
  under inert gas
color   white
solubility   H2O: >10 mg/mL
  DMSO: 12 mg/mL
  ethanol: 3 mg/mL
SMILES string   OC(=O)\C=C/C(O)=O.S=C(CC1CCCCC1)N2CCC(CC2)c3c[nH]cn3
InChI   1S/C16H25N3S.C4H4O4/c20-16(10-13-4-2-1-3-5-13)19-8-6-14(7-9-19)15-11-17-12-18-15;5-3(6)1-2-4(7)8/h11-14H,1-10H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key   REZRBLGMJZZSID-BTJKTKAUSA-N
Gene Information   human ... HRH3(11255)

Description

Application

Thioperamide maleate salt was used to study the sympathetic and autonomic nerve activity in mammalian white adipose tissue.

Packaging

10, 25, 100 mg in poly bottle

Biochem/physiol Actions

Potent and selective H3 histamine receptor antagonist that crosses the blood-brain barrier.

Thioperamide is a potent and selective H3 histamine receptor antagonist that crosses the blood-brain barrier. It affects the central histaminergic system and decreases the duration of seizures and convulsions in mice. It also improves learning deficit induced by other drugs such as scopolamine.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?