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T1327 Sigma-Aldrich

Tissue Inhibitor of Metalloproteinase-3 human

recombinant, expressed in NSO cells, >95% (SDS-PAGE)

Synonym: TIMP-3

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience,
recombinant   expressed in NSO cells
assay   >95% (SDS-PAGE)
form   lyophilized powder
mol wt   apparent mol wt ~30 kDa
storage temp.   −20°C
Gene Information   human ... TIMP3(7078)

Description

Biochem/physiol Actions

The TIMPs are endogenous inhibitors of the matrix metalloproteinases (MMPs). TIMP-3 inhibits ADAM-17 (TACE) at nanomolar concentrations and also inhibits other metalloproteinases (sheddases) that mediate the shedding of soluble receptors and other proteins from the surface of cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in 25 mM Tris and 0.15 M sodium chloride, pH 7.5.

Analysis Note

The biological activity is measured by its ability to inhibit human MMP-2 hydrolysis of a peptide substrate.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis

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Certificate of Origin

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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