T144 Sigma-Aldrich


≥98%, powder

Synonym: (±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

  • CAS Number 50-35-1

  • Empirical Formula (Hill Notation) C13H10N2O4

  • Molecular Weight 258.23

  •  EC Number 200-031-1

  •  MDL number MFCD00153873

  •  eCl@ss 39180303

  •  PubChem Substance ID 24278765

  •  NACRES NA.77



Related Categories Angiogenesis, Angiogenesis Inhibitors, Angiogenesis Regulators, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index,
assay   ≥98%
form   powder
color   white
solubility   DMSO: 20 mg/mL, clear
originator   Celgene
SMILES string   O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1
InChI   1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
Gene Information   human ... LITAF(9516), TNF(7124)
mouse ... Nos2(18126)
rat ... Nos1(24598)



Thalidomide has been used to study its neuropathological effects in mouse models of Alzheimer′s disease (AD). This study reported that long term administration of thalidomide causes beta-secretase inhibition and subsequently alleviates amyloid-like pathology. Furthermore, thalidomide has also been used to evaluate its teratogenic functions. Thalidomide was found to affect endodermal differentiation and neural development in differentiating human embryonic and induced pluripotent stem cells.


1 g in glass bottle

100 mg in glass bottle

Biochem/physiol Actions

(±)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). It also functions as an inhibitor of angiogenesis, an immunosuppressive agent, a sedative and a teratogen. Furthermore, thalidomide is known to exhibit antitumor functions in refractory multiple myeloma.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by Celgene. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Thalidomide is soluble in DMSO at a concentration that is more than 20 mg/ml. It is insoluble in water and ethanol.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T144.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
UN 2811 6.1 / PGIII
WGK Germany 


Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

Please Enter a Lot Number
Protocols & Articles


HPLC Analysis of Thalidomide Enantiomers on Astec® CHIROBIOTIC® V2

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Thalidomide Enantiomers on Astec® CHIROBIOTIC® V2
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Thalidomide Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Thalidomide Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

Peer-Reviewed Papers


Related Products

related product

Product #


Add to Cart

901830 Pomalidomide-PEG4-NH2 hydrochloride, ≥95%
901860 (S,R,S)-AHPC-PEG6-NH2 hydrochloride, ≥95%
903434 Pomalidomide-PEG6-butyl azide, ≥95%
903442 Pomalidomide-PEG6-butyl iodide, ≥95%
903833 Pomalidomide-PEG2-azide
903825 Pomalidomide-PEG1-azide
903957 (S,R,S)-AHPC-PEG1-azide
904651 (S,R,S)-AHPC-PEG3-azide, ≥95%
904724 Pomalidomide-PEG2-butyl iodide, ≥95%
904708 Pomalidomide-C6-PEG3-butyl iodide, ≥95%
904678 Pomalidomide-PEG3-azide
904686 Pomalidomide-C6-PEG3-butyl azide, ≥95%
904813 (S,R,S)-AHPC-PEG2-azide
904821 (S,R,S)-AHPC-C6-PEG3-butyl azide, ≥95%
904880 Pomalidomide-C6-PEG1-C3-PEG1-butyl azide, ≥95%
904872 Pomalidomide-PEG2-butyl azide, ≥95%
904864 (S,R,S)-AHPC-PEG6-butyl azide, ≥95%
905224 Pomalidomide-PEG6-butyl amine hydrochloride, ≥95%

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?