• USA Home
  • T1952 - Trichostatin A, Ready Made Solution

T1952 Sigma-Aldrich

Trichostatin A, Ready Made Solution

5 mM in DMSO (0.2 μm-filtered), from Streptomyces sp.

Synonym: TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

  • CAS Number 58880-19-6

  • Empirical Formula (Hill Notation) C17H22N2O3

  • Molecular Weight 302.37

  •  NACRES NA.32



Related Categories Antibiotic Ready Made Solutions, Antibiotics, Bioactive Small Molecules for Epigenetic Research, Biochemicals and Reagents, Cell Biology,
Quality Level   200
biological source   Streptomyces sp.
form   DMSO solution
concentration   5 mM in DMSO (0.2 μm-filtered)
Mode of action   enzyme | inhibits
antibiotic activity spectrum   fungi
shipped in   dry ice
storage temp.   −20°C


General description

Trichostatin A is a compound of primary hydroxamic acid.


Trichostatin A, ready-made solution has been used:
• as a histone deacetylase inhibitor to study its effect on transcriptome changes by stem cell testing
• to inhibit histone deacetylase (HDAC) class I, II, or III in primary pituitary cell cultures and to investigate insulin control of endogenous human growth hormone gene (hGH)
• to treat cells for the HDAC inhibition experiments

Biochem/physiol Actions

Trichostatin A (TSA) is a Streptomyces metabolite, which specifically inhibits mammalian histone deacetylase at a nanomolar concentration and causes accumulation of highly acetylated histone molecules in mammalian cells. For that reason, trichostatin A is a tool to study the consequences of histone acetylation in vivo. Trichostatin A induces cell differentiation, cell cycle arrest, reversal of transformed cells morphology, and apoptosis and is able to modulate transcription. TSA has been used to establish a new cloning technique, which increases the success rates for mouse cloning.

Safety & Documentation

Safety Information

NA 1993 / PGIII
WGK Germany 


Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers


Related Products

related product

Product #


Add to Cart

T8552 Trichostatin A, ≥98% (HPLC), from Streptomyces sp.
EPI003 In Situ Histone Deacetylase (HDAC) Activity Fluorometric Assay Kit, 100 assays in 96 well plates
EPI004 Histone Deacetylase 3 (HDAC3) Activity Assay Kit, 100 assays in 96 well plates
EPI005 Histone Deacetylase 3 (HDAC3) Inhibitor Screening Kit, 100 assays in 96 well plates
EPI006 Histone Deacetylase 8 (HDAC8) Activity Assay Kit, 100 assays in 96 well plates
EPI007 Histone Deacetylase 8 (HDAC8) Inhibitor Screening Kit, 100 assays in 96 well plates
EPI008 Histone Deacetylase (HDAC) Inhibitor Set I, Set includes 6 inhibitors
EPI009 Histone Deacetylase (HDAC) Inhibitor Set II, Set includes 7 inhibitors
92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?