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  • T2190 - Anti-Tumor Necrosis Factor Soluble Receptor I antibody produced in goat

T2190 Sigma-Aldrich

Anti-Tumor Necrosis Factor Soluble Receptor I antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-TNFsRI



Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies for Hematopoietic Stem Cells,
conjugate   unconjugated
clone   polyclonal
biological source   goat
application(s)   flow cytometry: suitable
  immunohistochemistry (frozen sections): suitable
  western blot: suitable
species reactivity   mouse
form   lyophilized powder
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   100
antibody product type   primary antibodies
UniProt accession no.   P25118
Gene Information   mouse ... Tnfrsf1a(21937)


General description

The antibody recognizes cell surface mouse TNF RI (55 kDa) and exhibits TNF agonist activities. The antibody shows < 5% cross-reactivity with recombinant human TNF sRI and no cross-reactivity with recombinant human TNFsRII.


recombinant mouse TNF soluble receptor I, expressed in Escherichia coli.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose.

Biochem/physiol Actions

The biological effects of tumor necrosis factor soluble factor (TNSF) are mediated by either type I or type II receptors. Type I receptors that are ubiquitously present on all cells whereas type II receptors are expressed only on cells of immune system and endothelial cells. Receptors of TNFSF such as TNFR1 and Fas have their own death domains that activate the apoptosis. Other receptors such as TNFR2 do not have death domains and utilize TNF associated factors (TRAFs) to activate intracellular signaling. The pathways activated via TNFsRI include NF-κB, JNK and MAPK.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles


Antibody Basics

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Western Blot Protocol | Immunoblotting Protocol

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