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T2255 Sigma-Aldrich

Trifluorothymidine

≥99% (HPLC)

Synonym: α,α,α-Trifluorothymidine, 2′-Deoxy-5-trifluoromethyluridine, Trifluorothymine deoxyriboside, Trifluridine

  • CAS Number 70-00-8

  • Empirical Formula (Hill Notation) C10H11F3N2O5

  • Molecular Weight 296.20

  •  EC Number 200-722-8

  •  MDL number MFCD00006534

  •  PubChem Substance ID 24900027

  •  NACRES NA.51

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Properties

Related Categories Biochemicals and Reagents, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides More...
biological source   synthetic
assay   ≥99% (HPLC)
form   powder
mp   190-193 °C (lit.)
solubility   water: 50 mg/mL, clear, colorless
storage temp.   −20°C
SMILES string   OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(C(=O)NC2=O)C(F)(F)F
InChI   1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1
InChI key   VSQQQLOSPVPRAZ-RRKCRQDMSA-N

Description

Application

Trifluorothymidine (Trifluridine, TFT) is a substrate used to study the specificity and kinetics of thymidine kinase(s). TFT after phosphorylation may be incorporated into DNA where is induces DNA-damage, consequently TFT is useful for studies of DNA repair mechanisms. TFT may also be used to study mechanisms of inhibition of thymidylate synthase(s).

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T2255.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
XP2087500

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

HPLC Analysis of Fluorinated Pyrimidine Nucleosides on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Fluorinated Pyrimidine Nucleosides on Ascentis® RP-Amide
Keywords: Chromatography, Clinical, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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