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T2265 Sigma-Aldrich

Tetraethylammonium chloride

≥98% (titration)

Synonym: TEA chloride

  • CAS Number 56-34-8

  • Linear Formula (C2H5)4N(Cl)

  • Molecular Weight 165.70

  •  Beilstein/REAXYS Number 3563247

  •  EC Number 200-267-5

  •  MDL number MFCD00011828

  •  PubChem Substance ID 24277874

  •  NACRES NA.32

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Monovalent Ion Channels, Potassium Channel Modulators,
Quality Level   200
biological source   synthetic (organic)
assay   ≥98% (titration)
form   powder
application(s)   blocking: suitable
color   white to light yellow
SMILES string   [Cl-].CC[N+](CC)(CC)CC
InChI   1S/C8H20N.ClH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1
InChI key   YMBCJWGVCUEGHA-UHFFFAOYSA-M
Gene Information   human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143)

Description

Application

Tetraethylammonium chloride (TEAC) has been used:
• used for inhibition of peroxynitrite induced relaxation in rat aorta rings
• as a pharmacological blocker of K+ current and Ca2+ induced K+ current in antennal lobe neurons
• for the induction of TEAC sensitive currents in cochlear inner hair cells digested with proteolytic enzymes and analyze its properties

Biochem/physiol Actions

Blocks K+ channels; blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K+ currents.

Tetraethylammonium chloride (TEAC) blocks K+ channels non-specifically. In rat aorta rings, tetraethylammonium inhibits relaxation induced by peroxynitrite. It blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K+ currents. TEAC can increase the contractility and mobility of colon and rectum and is a therapeutic option for Hirschsprung′s disease patients. TEAC reduces the inflammatory responses, improves cardiac, vascular and hemodynamic properties during early sepsis in animals. TEAC has cytotoxic and anti-proliferative potential and induces apoptosis in glioma cells by downregulating B-cell lymphoma-2 (Bcl-2) and upregulating Bcl-2 associated X (Bax).

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Caution

moisture sensitive, handle under argon

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
BS6125000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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