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T3125 Sigma-Aldrich

Tetrahydrofolic acid

≥65% (when packaged), powder

Synonym: 5,6,7,8-Tetrahydropteroyl-L-glutamic acid, THF

  • CAS Number 135-16-0

  • Empirical Formula (Hill Notation) C19H23N7O6

  • Molecular Weight 445.43

  •  Beilstein/REAXYS Number 9238187

  •  EC Number 205-181-1

  •  MDL number MFCD00135583

  •  PubChem Substance ID 24900106

  •  NACRES NA.51

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cofactor, Cofactors, Enzymes, Inhibitors, and Substrates,
InChI Key   MSTNYGQPCMXVAQ-KIYNQFGBSA-N
Quality Level   200
assay   ≥65% (when packaged)
form   powder
color   faintly yellow to light brown
storage temp.   −20°C

Description

Application

A recent use of tetrahydrofolate (THF) is for the studying the activation of riboswitches.

Tetrahydrofolic acid has been used to determine the inhibitory effect of tetrahydrofolate on polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs).

Biochem/physiol Actions

Tetrahydrofolic acid is the parent molecule of the folate derivatives that donate one-carbon units to amino acids, nucleic acids, and lipids. Tetrahydrofolate metabolites participate in the synthesis of purine and pyrimidine and in synthesis and conversion of amino acids

Packaging

Sealed ampule.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T3125.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
MA0600800

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Folic Acid Metabolism: A Role in Cancer's Cause and Cure

The mammalian folic acid cycle is a highly complex but crucial process for the transfer of one-carbon units to amino acids, nucleotides, and other biomolecules. Folic acid cannot be synthesized but i...
Biofiles Vol. 5, No. 6
Keywords: Antibiotics, Antitumor agents, Apoptosis, Building blocks, Cancer, Cellular processes, Eliminations, Gastrointestinal, Metabolic Pathways, Metabolism, Metabolites, Methylations, Phosphorylations, Purine synthesis, Reductions, transformation

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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